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NeoSome offers a comprehensive approach for evaluating anti-infective agents.
We can support your program from initial in vitro assessment, through tolerability testing, primary in vivo screening to target organ efficacy, and PK/PD evaluations.
We customize our animal models to fit your project goals and timelines.
Many models are “ready to run”. We can modify these animal models to suit your program needs including susceptible and resistance isolates, prophylactic and therapeutic dosing schedules, multiple administration routes, and regimens.
Neutropenic Rat thigh infection model with MRSA IV dose administration of test agents Bio-burden determined in thigh muscle.
Neutropenic Rat pneumonia model with MRSA SC dose administration of test agents Bio-burden determined in lung tissue.
Infection via IV injection Therapy initiated 2 hours post infection Bioburden assessed in kidneys and bladder at 26 hours
From design to study execution to data analysis, we can provide a comprehensive package to advance your programs to the next steps.
Mouse Protection Test; septicemia, bacteremia
Mouse subcutaneous abscess model
Rodent Pulmonary models – rat, mouse
Rodent kidney infection model
PK/PD determinations and modeling
C. difficile mouse and hamster models
Mouse skin infection model - superficial and full thickness
Neutropenic models - thigh and lung infection
Selected organ infection models - eye, kidney, skin etc
Prophylactic and therapeutic model designs
Yeast and fungal infection models - kidney, lung, skin, vaginal